Мы используем Cookies Этот веб-сайт использует cookie-файлы, чтобы предлагать вам наиболее актуальную информацию. Просматривая этот веб-сайт, Вы принимаете cookie-файлы.
The xenograft leukemia model with stable multipledrugresistance in nude mice was established.
2
These results suggest that doxorubicin resistance is multifactorial and alternative mechanisms of multipledrugresistance remain to be determined.
3
These data cumulatively suggest that the taccalonolides have advantages over the taxanes in their ability to circumvent multipledrugresistance mechanisms.
4
The multipledrugresistance protein 1 (MRP1 or ABCC1) transports anticancer drugs and normal cell metabolites.
5
Chemotherapy and targeted therapy can significantly improve survival rates in cancer, but multipledrugresistance (MDR) limits the efficacy of these approaches.
1
Possible contributors include multidrugresistance, extensive virulence gene content, and ongoing transmission.
2
The study showed that elevated hsps were not associated with multidrugresistance.
3
These results hold significant implications for the study of multidrugresistance in vivo.
4
Silymarin complex was previously described as an antioxidant with multidrugresistance modulation activity.
5
We are concerned about the multidrugresistance of A. baumannii in this study.
1
Although more subjective, there is also no consensus regarding the definition of multiresistance.
1
Cases of multi-drugresistance were recorded in the present study and require further consideration.
2
The development of non-P-glycoprotein-mediated multi-drugresistance is a frequent event among lung-cancer cell lines.
3
Background: Efflux pumps of the Resistance-Nodulation-cell Division superfamily confer multi-drugresistance to Gram-negative bacteria.
4
In summary, there may be a significant contribution of transcriptional activation to multi-drugresistance.
5
High Glo1 expression is a cause of multi-drugresistance.
Использование термина mdr на английском
1
The mammalian mdr gene family comprises a small number of closely related genes.
2
Expression levels of each mdr gene are dramatically different in various mouse tissues.
3
Each of the mdr genes has a specific RNA transcript pattern.
4
Tet could downregulate the level of mdr-1 gene and decrease the expression of P-gp.
5
In addition, a number of strategies aimed at reversing the mdr phenotype are under study.
6
H17 proved to be more active than cyclosporine A as a known strong mdr modulator.
7
We have identified distinct mdr gene transcripts encoded by three separate mdr genes in the mouse.
8
In this report, we characterize a second member of the mdr gene family which we designated mdr2.
9
These results should be considered in relation to understanding the normal physiological function of the mdr multigene family.
10
The mdr-1 level was measured in 44 biopsies from 19 patients.
11
Our results demonstrate that overexpression of a single member of the mdr group is sufficient to confer drug resistance.
12
It was previously demonstrated that multidrug-resistant Chinese hamster cell lines contain an amplified, transcriptionally active DNA sequence designated mdr.
13
However, the direct relationship, if any, of this new member of the mdr family to multidrug resistance remains to be established.
14
Multidrug resistance in mammalian tumor cells is associated with the overexpression of mdr genes encoding P-glycoproteins, which function as drug efflux pumps.
15
Alternatively, some groups are investigating transfecting the mdr gene into bone marrow cells to reduce the sensitivity of these cells to cytotoxic agents.
16
In these cell lines high levels of resistance are frequently associated with amplification and overexpression of a small group of genes termed mdr or gp170.